The transfer of the portfolio is the latest move from Barclays as it looks to reduce its capital requirements.
The majority of buy-side firms, including pension funds, are expected to begin clearing of derivatives from the second half of 2017.
Eurex Clearing is the sixth non-US CCP to win CFTC approval for derivatives clearing.
Incoming rules on electronic swaps trading have yet to persuade institutional investors.
Full registration for smaller swaps trading venues could remove uncertainty and open up liquidity.
Compression services are increasingly being adopted by banks to reduce derivatives exposures.
The derivatives industry has seen execution costs for USD swaps contracts fall by as much as $40 million daily since the onset of new trading rules, according to research from the Bank of England.
trueFIX platform aims to offer real-time, automated trading of dollar, euro and sterling interest rate swaps.
US derivatives regulators plan to overhaul swaps reporting in order to streamline and improve the quality of reports.